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R. Gerstberger is at the Max Planck Institute for Physiological and Clinical Research, W.G. Kerckhoff Institute, Parkstrasse 1, D-61231 Bad Nauheim, Germany.
Pharmacological studies of thermoregulatory effector and neuronal responses indicate that nitric oxide (NO) may have differential roles in the control of body temperature and during fever. Histochemical analysis of site-specific changes in NO synthase activity in defined states of thermal stimulation appears a promising approach to unravel the underlying hypothalamic neuronal cytoarchitecture.
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