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Regulation of Cellular Growth by 1,25-Dihydroxyvitamin D₃-Mediated Growth Factor Expression

Timothy D. Veenstra, Mark R. Pittelkow and Rajiv Kumar

T. D. Veenstra is in the Nephrology Research Unit; M. R. Pittelkow is in the Department of Dermatology and the Department of Biochemistry and Molecular Biology; and R. Kumar is in the Nephrology Research Unit and the Department of Biochemistry and Molecular Biology at the Mayo Clinic/Foundation, Rochester, MN 55905, USA.
Although the primary function of 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] is the regulation of calcium and phosphorus metabolism, it also regulates the growth and differentiation of several different cell types. Recent work suggests that 1,25(OH)₂D₃ regulates cellular growth by altering the synthesis of growth factors and growth factor responses.

This article has been cited by other articles:

				A. Gurlek, M. R. Pittelkow, and R. Kumar Modulation of Growth Factor/Cytokine Synthesis and Signaling by 1{alpha},25-Dihydroxyvitamin D3: Implications in Cell Growth and Differentiation Endocr. Rev., December 1, 2002; 23(6): 763 - 786. [Abstract] [Full Text] [PDF]