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SCFAs: The Enigma of Weak Electrolyte Transport in the Colon

Joseph H. Sellin

J. H. Sellin is Professor of Medicine and Director of the Division of Gastroenterology at the University of Texas Medical School at Houston, PO Box 20708, Houston, TX 77225, USA.
Short-chain fatty acids are the predominant luminal anions in the colon (>75 mM) and thus create a rather unique environment for transporting epithelium. The colon absorbs short-chain fatty acids, either by diffusion of the protonated species across the apical membrane or by an anion exchange process with bicarbonate. Additionally, short-chain fatty acids modulate Na absorption, Cl secretion, intracellular pH, and cell volume.

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