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News Physiol Sci 14: 74-80, 1999;
1548-9213/99 $5.00
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News in Physiological Sciences, Vol. 14, No. 2, 74-80, April 1999
© 1999 Int. Union Physiol. Sci./Am. Physiol. Soc.

A Unique Role of NO in the Control of Blood Flow

Ulrich Pohl and Cor de Wit

U. Pohl and C. de Wit are in the Physiologisches Institut of Ludwig Maximilians Universität, Pettenkoferstr. 12, D-80336, München, Germany.
Nitric oxide synthase (NOS) inhibitors induce significant vasoconstriction, suggesting an indispensable role of NO as a local vasodilator. This is due mainly to its effects on large arterioles that significantly control arterial conductance while scarcely being regulated by metabolites. NO's role in adapting vascular conductance to flow is pronounced during (re)active hyperemia and autoregulation.




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