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News Physiol Sci 14: 80-84, 1999;
1548-9213/99 $5.00
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News in Physiological Sciences, Vol. 14, No. 2, 80-84, April 1999
© 1999 Int. Union Physiol. Sci./Am. Physiol. Soc.

Renal Transport of Urate in Humans

Françoise Roch-Ramel and Barbara Guisan

F. Roch-Ramel is Professor and B. Guisan is a specialized technician from the Institut de Pharmacologie et Toxicologie, Bugnon 27, CH1005 Lausanne, Switzerland.
The theory of the "four-component model" of urate excretion in humans is reevaluated, considering that a decrease in urate excretion induced by drugs like pyrazinamide or by endogenous compounds like lactate and ketone bodies might be a result of stimulation of urate reabsorption and not, as previously considered, of inhibition of urate secretion.




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