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News Physiol Sci 14: 121-125, 1999;
1548-9213/99 $5.00
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News in Physiological Sciences, Vol. 14, No. 3, 121-125, June 1999
© 1999 Int. Union Physiol. Sci./Am. Physiol. Soc.

Arteriogenesis Versus Angiogenesis: Two Mechanisms of Vessel Growth

I. Buschmann and W. Schaper

I. Buschmann and W. Schaper are in the Department for Experimental Cardiology of the Max Planck Institute for Physiological and Clinical Research, Benekestrasse 2, D-61231 Bad Nauheim, Germany.
After birth, new blood vessel formation proceeds via angiogenesis or arteriogenesis. Angiogenesis (capillary sprouting) results in higher capillary density. Arteriogenesis (rapid proliferation of collateral arteries) is potentially able to significantly alter the outcome of coronary and peripheral artery disease. The processes share some growth features but differ in many aspects.




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