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Ca²⁺ Sparks in Cardiac Muscle: Is There Life Without Them?

Ernst Niggli

E. Niggli is in the Department of Physiology, University of Bern, 3012 Bern, Switzerland (E-mail: niggli{at}pyl.unibe.ch; http://beam.to/calcium_quark).
The discovery of elementary Ca²⁺ signaling events, the Ca²⁺ sparks, has profoundly changed our view of cardiac Ca²⁺ signaling and, in particular, excitationcontraction coupling. In addition, a partial disruption of cardiac Ca²⁺ signaling may be important in clinical cardiac conditions such as congestive heart failure. Understanding cardiac diseases on the cellular and molecular levels may provide a key to new pharmacological strategies in the near future.

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