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News Physiol Sci 14: 135-142, 1999;
1548-9213/99 $5.00
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News in Physiological Sciences, Vol. 14, No. 4, 135-142, August 1999
© 1999 Int. Union Physiol. Sci./Am. Physiol. Soc.

The ether-à-go-go-Related Gene K+ Current: Functions of a Strange Inward Rectifier

Jürgen R. Schwarz and Christiane K. Bauer

J. R. Schwarz and C. K. Bauer are in the Abteilung für angewandte Physiologie, Physiologisches Institut, Universitäts-Krankenhaus Eppendorf, Universität Hamburg, D-20246 Hamburg, Germany.
The erg channels mediate an inward-rectifying K+ current because of their peculiar gating kinetics. They are involved in repolarization of the cardiac action potential, frequency adaptation, and maintenance of the resting potential. Reduction of erg currents via an intracellular signal cascade underlies the thyrotropin-releasing hormone-induced increase in prolactin secretion.




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