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P. J. Magistretti and L. Pellerin are in the Institut de Physiologie, Faculté de Médecine, Université de Lausanne, CH-1005 Lausanne, Switzerland.
Astrocytes have functional characteristics that make them particularly well suited to couple glutamate uptake from the synaptic cleft to Na+-K+-ATPase activation and glucose utilization. The changes in glucose metabolism associated with these processes may provide signals detected by positron emission tomography.
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