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News Physiol Sci 14: 177-182, 1999;
1548-9213/99 $5.00
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News in Physiological Sciences, Vol. 14, No. 5, 177-182, October 1999
© 1999 Int. Union Physiol. Sci./Am. Physiol. Soc.

Astrocytes Couple Synaptic Activity to Glucose Utilization in the Brain

Pierre J. Magistretti and Luc Pellerin

P. J. Magistretti and L. Pellerin are in the Institut de Physiologie, Faculté de Médecine, Université de Lausanne, CH-1005 Lausanne, Switzerland.
Astrocytes have functional characteristics that make them particularly well suited to couple glutamate uptake from the synaptic cleft to Na+-K+-ATPase activation and glucose utilization. The changes in glucose metabolism associated with these processes may provide signals detected by positron emission tomography.




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