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M. P. Hlastala and R. W. Glenny are in the Department of Physiology and Biophysics and the Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington, Box 356522, Seattle, WA 98195-6522, USA.
Scientific knowledge develops through the evolution of new concepts. This process is usually driven by new methodologies that provide observations not previously available. Understanding of pulmonary blood flow determinants advanced significantly in the 1960s and is now changing rapidly again, because of increased spatial resolution of regional pulmonary blood flow measurements.
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