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Physiology of Receptor-Mediated Lymphocyte Apoptosis

F. Lang, I. Szabo, A. Lepple-Wienhues, D. Siemen and E. Gulbins

F. Lang, I. Szabo, A. Lepple-Wienhues, D. Siemen, and E. Gulbins are in the Department for Physiology of the University of Tübingen, Gmelinstrasse 5, D-72076 Tübingen, Germany.
Apoptosis (programmed cell death), a physiological mechanism eliminating abundant and potentially harmful cells, is triggered by a variety of stimuli including activation of distinct receptors. The machinery mediating CD95 receptor-induced apoptosis includes caspases, ceramide, kinases, Ras and Rac, formation of O₂^–, mitochondrial proteins, inhibition of K⁺ channels, activation of Cl^– channels, and osmolyte release.

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