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News Physiol Sci 14: 201-206, 1999;
1548-9213/99 $5.00
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News in Physiological Sciences, Vol. 14, No. 5, 201-206, October 1999
© 1999 Int. Union Physiol. Sci./Am. Physiol. Soc.

Visceral Afferent Neurons: Role in Gastric Mucosal Protection

Peter Holzer and Maria A. Pabst

P. Holzer is Professor in the Department of Experimental and Clinical Pharmacology, University of Graz, Universitätsplatz 4, A-8010 Graz, Austria. M. A. Pabst is Professor in the Department of Histology and Embryology, University of Graz, Harrachgasse 21, A-8010 Graz, Austria.
Gastric mucosal homeostasis requires rapid alarm of protective mechanisms in the face of pending injury. This article summarizes the evidence that spinal afferent neurons monitor insults to the gastric mucosa and activate local mechanisms of defense and repair through release of transmitter peptides from their endings in the stomach.







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