HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Karschin, A. Search for Related Content PubMed PubMed Citation Articles by Karschin, A.

G Protein Regulation of Inwardly Rectifying K⁺ Channels

Andreas Karschin

A. Karschin is at the Molecular Neurobiology of Signal Transduction Team, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37070 Göttingen, Germany.
Inwardly rectifying K⁺ (Kir) channels respond to receptor-stimulated signaling cascades that involve G proteins and other cytosolic messengers. Channel activity is controlled both by direct coupling of G protein subunits and by phosphorylation via protein serine/threonine and tyrosine kinases. The coincidence of both forms of Kir channel signaling may give rise to complex cellular responses.

This article has been cited by other articles:

				N. Voigt, A. Friedrich, M. Bock, E. Wettwer, T. Christ, M. Knaut, R. H. Strasser, U. Ravens, and D. Dobrev Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillation Cardiovasc Res, June 1, 2007; 74(3): 426 - 437. [Abstract] [Full Text] [PDF]

				A. Kulik, I. Vida, Y. Fukazawa, N. Guetg, Y. Kasugai, C. L. Marker, F. Rigato, B. Bettler, K. Wickman, M. Frotscher, et al. Compartment-dependent colocalization of Kir3.2-containing K+ channels and GABAB receptors in hippocampal pyramidal cells. J. Neurosci., April 19, 2006; 26(16): 4289 - 4297. [Abstract] [Full Text] [PDF]

				S. Choi, S.-Y. Jung, Y.-S. Ko, S.-R. Koh, H. Rhim, and S.-Y. Nah Functional Expression of a Novel Ginsenoside Rf Binding Protein from Rat Brain mRNA in Xenopus laevis Oocytes Mol. Pharmacol., April 1, 2002; 61(4): 928 - 935. [Abstract] [Full Text] [PDF]

				T. Meyer, M.-C. Wellner-Kienitz, A. Biewald, K. Bender, A. Eickel, and L. Pott Depletion of Phosphatidylinositol 4,5-Bisphosphate by Activation of Phospholipase C-coupled Receptors Causes Slow Inhibition but Not Desensitization of G Protein-gated Inward Rectifier K+ Current in Atrial Myocytes J. Biol. Chem., February 16, 2001; 276(8): 5650 - 5658. [Abstract] [Full Text] [PDF]

				C. Dart and M. L. Leyland Targeting of an A Kinase-anchoring Protein, AKAP79, to an Inwardly Rectifying Potassium Channel, Kir2.1 J. Biol. Chem., June 1, 2001; 276(23): 20499 - 20505. [Abstract] [Full Text] [PDF]

				K. Bender, M.-C. Wellner-Kienitz, A. Inanobe, T. Meyer, Y. Kurachi, and L. Pott Overexpression of Monomeric and Multimeric GIRK4 Subunits in Rat Atrial Myocytes Removes Fast Desensitization and Reduces Inward Rectification of Muscarinic K+ Current (IK(ACh)). EVIDENCE FOR FUNCTIONAL HOMOMERIC GIRK4 CHANNELS J. Biol. Chem., July 27, 2001; 276(31): 28873 - 28880. [Abstract] [Full Text] [PDF]

				M.-C. Wellner-Kienitz, K. Bender, and L. Pott Overexpression of beta 1 and beta 2 Adrenergic Receptors in Rat Atrial Myocytes. DIFFERENTIAL COUPLING TO G PROTEIN-GATED INWARD RECTIFIER K+ CHANNELS VIA Gs AND Gi/o J. Biol. Chem., September 28, 2001; 276(40): 37347 - 37354. [Abstract] [Full Text] [PDF]