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A. Karschin is at the Molecular Neurobiology of Signal Transduction Team, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37070 Göttingen, Germany.
Inwardly rectifying K+ (Kir) channels respond to receptor-stimulated signaling cascades that involve G proteins and other cytosolic messengers. Channel activity is controlled both by direct coupling of G protein subunits and by phosphorylation via protein serine/threonine and tyrosine kinases. The coincidence of both forms of Kir channel signaling may give rise to complex cellular responses.
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