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R. J. Roman is Professor and M. Alonso-Galicia is Postdoctoral Fellow in the Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.
Cytochrome P-450 enzymes primarily metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) in the kidney. These compounds serve as second messengers that play a central role in the regulation of renal vascular tone and sodium reabsorption in the proximal tubule and thick ascending loop of Henle.
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