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News Physiol Sci 14: 249-255, 1999;
1548-9213/99 $5.00
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News in Physiological Sciences, Vol. 14, No. 6, 249-255, December 1999
© 1999 Int. Union Physiol. Sci./Am. Physiol. Soc.

The Reward Signal of Midbrain Dopamine Neurons

Wolfram Schultz

W. Schultz is in the Institute of Physiology of the University of Fribourg, CH-1700 Fribourg, Switzerland.
Dopamine projections from the midbrain to striatum and frontal cortex play a major role in behavioral reactions controlled by rewards. Recent experiments have shown that dopamine neurons code the discrepancy between the prediction and occurrence of rewards and in this way signal a crucial learning term for approach behavior.




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