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News Physiol Sci 14: 255-259, 1999;
1548-9213/99 $5.00
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News in Physiological Sciences, Vol. 14, No. 6, 255-259, December 1999
© 1999 Int. Union Physiol. Sci./Am. Physiol. Soc.

Adrenomedullin: Is There Physiological Relevance in the Pathology and Pharmacology?

Willis K. Samson, Zachary T. Resch, Tonya C. Murphy, Trini T. Vargas and Debra A. Schell

W. K. Samson is in the Department of Pharmacological and Physiological Sciences, St. Louis University School of Medicine, 1402 S. Grand Blvd., St. Louis, MO 63104; Z. T. Resch, T. C. Murphy, and D. A. Schell are in the Department of Physiology, University of North Dakota School of Medicine and Health Sciences, 501 N. Columbia Rd., Grand Forks, ND 58202; and T. T. Vargas is in the Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555-0359, USA.
The adrenomedullin gene encodes two potent hypotensive peptides, adrenomedullin and proadrenomedullin NH2-terminal 20 peptide. As with other vasoactive peptides, the most difficult challenge is to prove the physiological relevance of their recognized pathological and pharmacological actions and to establish, against that physiological background, their therapeutic potential.




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