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From Limbs to Lungs: A Newt Perspective on Compensatory Lung Growth

Kirk A. Gilbert and D. Eugene Rannels

K. A. Gilbert is in the Department of Cellular and Molecular Physiology and D. E. Rannels is in the Department of Cellular and Molecular Physiology and the Department of Anesthesia at The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Partial lung resection initiates compensatory growth of remaining lobes to restore pulmonary structure and function. Mechanisms underlying this response are not well defined. This article considers molecular pathways involved in control of amphibian limb regeneration and tissue pattern formation for novel insight into the understanding of compensatory lung growth.

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