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The Discovery of Renin 100 Years Ago

M. Ian Phillips and K. M. Schmidt-Ott

M. I. Phillips and K. M. Schmidt-Ott are in the Department of Physiology of the University of Florida College of Medicine, Box 100274, Gainesville, FL 32610
In 1898, Tigerstedt and Bergman published their observation that kidney extracts produce pressor effects. They characterized the substance and named it "renin." Although this was the beginning of understanding the role of the kidney in hypertension and the renin-angiotensin system, their discovery lay dormant for nearly 40 years.

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