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M. Hecker is a professor in and Director of the Department of Cardiovascular Physiology, University of Goettingen, Humboldtallee 23, 37073 Goettingen, Germany.
The vascular endothelium releases a diffusible factor that hyperpolarizes and hence relaxes vascular smooth muscle cells predominantly through activation of Ca2+-dependent K+ channels. In the coronary circulation, this endothelium-derived hyperpolarizing factor appears to be a cytochrome P450-derived arachidonic acid epoxide, the release of which may play a crucial role in the maintenance of coronary blood flow in arteriosclerosis.
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