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News Physiol Sci 15: 15-19, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 1, 15-19, February 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

Extracellular Surface Charges in Voltage-Gated Ion Channels

Michael Madeja

M. Madeja is in the Institute for Physiology, University of Münster, Robert-Koch-Str. 27a D-48149 Münster, Germany.
A large number of charged amino acids are in the extracellularly located parts of the voltage-gated ion channels. Recent findings suggest that these surface charges contribute to the channel functions in the sensing of voltage, the binding of substances, and the sensing of H+ concentration.




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