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News Physiol Sci 15: 26-33, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 1, 26-33, February 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

Sarcomeric Myosin Isoforms: Fine Tuning of a Molecular Motor

Carlo Reggiani, Roberto Bottinelli and Ger J. M. Stienen

C. Reggiani and R. Bottinelli are in the Institute of Human Physiology at the University of Pavia, I-27100 Pavia, Italy. G. J. M. Stienen is in the Laboratory for Physiology at the Free University, 1081 BT Amsterdam, the Netherlands.
Sarcomeric or striated muscle myosins are the molecular motors whose fine tuning is best known. Sarcomeric myosin isoforms convert chemical into mechanical energy at very different rates without losing efficiency. Availability of the amino acid sequences offers for the first time the chance to understand the molecular basis of the versatility of these molecular motors.




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