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News Physiol Sci 15: 33-41, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 1, 33-41, February 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

Images of Action Potential Propagation in Heart

Guy Salama and Bum-Rak Choi

G. Salama and B.-R. Choi are in the Department of Cell Biology and Physiology at the University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261.
Activation and repolarization across mammalian hearts follow complex three-dimensional pathways that are governed by fiber structure, intercellular coupling, and action potentials (APs) with spatially heterogeneous properties. Voltage-sensitive dyes and imaging techniques offer new insights on how spatiotemporal heterogeneities of APs govern propagation, repolarization, and AV node conduction and help us visualize arrhythmias with previously unattainable details.




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