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News Physiol Sci 15: 41-45, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 1, 41-45, February 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

Phospholipase C Isoforms, Cytoskeletal Organization, and Vascular Smooth Muscle Differentiation

Joanne S. Lymn and Alun D. Hughes

J. S. Lymn and A. D. Hughes are in the Department of Clinical Pharmacology, National Heart and Lung Institute, Imperial College School of Medicine, QEQM Wing, St. Mary's Hospital, Paddington, London W2 1NY, England.
The function of differentiated vascular smooth muscle cells (VSMC) in vivo is the regulation of contractility. Following injury or disease, however, VSMC lose their contractile function and take on a synthetic, proliferative phenotype. This dedifferentiation is generally accompanied by a change in the expression profile of phospholipase C isoforms.




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