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News Physiol Sci 15: 50-55, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 1, 50-55, February 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

Cytosolic Calcium Oscillations in Smooth Muscle Cells

Jean-Pierre Savineau and Roger Marthan

J. P. Savineau and R. Marthan are professors at the Laboratoire de Physiologie Cellulaire Respiratoire, INSERM (E n° 9937), Université Victor Ségalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cédex, France.
In a variety of smooth muscle cells, agonists activating membrane receptors induce oscillations in the cytoplasmic Ca2+ concentration via an inositol trisphosphate-activated mechanism. Ca2+ oscillations participate in the control of cell membrane potential and the tone of smooth muscle. There is evidence that alterations in Ca2+ oscillations modulate smooth muscle responsiveness.




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