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Bile Formation: a Concerted Action of Membrane Transporters in Hepatocytes and Cholangiocytes

Akos Zsembery, Theresia Thalhammer and Jürg Graf

A. Zsembery, T. Thalhammer, and J. Graf are in the Department of General and Experimental Pathology at the University Hospital Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
A large number of membrane transport mechanisms in hepatocytes and cholangiocytes serves for the secretion of bile acids, various other organic anions, organic cations, lipids, and electrolytes. After their functional characterization, some of these mechanisms' individual transport molecules are now identified, allowing better understanding of inherited and acquired disorders of bile formation.

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