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News Physiol Sci 15: 57-61, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 2, 57-61, April 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

CFTR Chloride Channels: Binding Partners and Regulatory Networks

Anjaparavanda P. Naren and Kevin L. Kirk

A. P. Naren and K. L. Kirk are in the Gregory Fleming James Cystic Fibrosis Research Center and the Department of Physiology and Biophysics at the University of Alabama at Birmingham, Birmingham, Alabama 35294. K. L. Kirk is also in the Department of Neurobiology.
The cystic fibrosis gene encodes a chloride channel (CFTR) that regulates transepithelial salt and water transport. Two classes of CFTR-binding proteins appear to link the opposing cytoplasmic tails of this channel to distinct regulatory networks. Such interactions may constitute new paradigms for modulating CFTR activity in health and disease.




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