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News Physiol Sci 15: 72-77, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 2, 72-77, April 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

The Cell Physiology of Biphasic Insulin Secretion

Patrik Rorsman, Lena Eliasson, Erik Renström, Jesper Gromada, Sebastian Barg and Sven Göpel

P. Rorsman, L. Elaisson, E. Renström, S. Barg, and S. Göpel are in the Department of Physiological Sciences, Division of Molecular and Cellular Physiology, Lund University, Sölvegatan 19, S-223 62 Lund, Sweden. J. Gromada is at Islet Cell Physiology, Building 1KS18, Novo Nordisk A/S, DK-2880 Bagsvaerd, Denmark.
Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes.




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