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News Physiol Sci 15: 78-83, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 2, 78-83, April 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

Mechanics of Relaxation of the Human Heart

Denis Chemla, Catherine Coirault, Jean-Louis Hébert and Yves Lecarpentier

D. Chemla, C. Coirault, J.-L. Hébert, and Y. Lecarpentier are in the Service de Physiologie Cardio-Respiratoire, CHU de Bicêtre, Assistance Publique-Hôpitaux de Paris, 94 275 Le Kremlin-Bicêtre, and Unité Inserm U451-Loa-Ensta-Ecole Polytechnique, 91 125 Palaiseau, France.
Rapid and complete relaxation is a prerequisite for cardiac output adaptation to changes in loading conditions, inotropic stimulation, and heart rate. In the healthy human heart, the rate and extent of relaxation depend mainly on actomyosin cross bridge dissociation and on left ventricular end-systolic volume, rather than on the afterload level.




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