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News Physiol Sci 15: 89-93, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 2, 89-93, April 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

Molecular Mechanisms in Bile Formation

Peter J. Meier and Bruno Stieger

P. J. Meier and B. Stieger are in the Division of Clinical Pharmacology and Toxicology, 1st Department of Medicine, University Hospital Zurich, CH-8091 Zurich, Switzerland.
Active canalicular secretion of bile salts and non-bile salt organic anions represents the major driving force of hepatic bile formation. The most important carriers involved have now been cloned on both the basolateral and canalicular sides of hepatocytes. Elucidation of their structure, transport properties, and regulation is an important step forward in the ultimate understanding of the molecular physiology of bile formation.




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