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Brain Stem Reflexes: Probing Human Trigeminal Nociception

Jens Ellrich

J. Ellrich is at the Friedrich-Alexander-University Institute of Physiology and Experimental Pathophysiology, Universitätsstrasse 17, D-91054 Erlangen, Germany.
Although many people suffer from orofacial pain and headache, objective methods for investigation of trigeminal nociception in humans have been lacking. Trigeminal brainstem reflexes such as the masseter inhibitory reflex and the blink reflex are mediated by central multireceptive neurons that are also involved in trigeminal nociception. Therefore, these trigeminal reflexes are suitable models for probing pontine and medullary pain processing.

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