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Exuberant Ca²⁺ Signaling in Neutrophils: A Cause for Concern

Mohammed M. Sayeed

M. M. Sayeed is in the Departments of Physiology and Surgery and the Burn and Shock Trauma Institute, Loyola University Medical Center, Maywood, IL 60153.
Under inflammatory conditions after burn/trauma injuries, circulating neutrophils are frequently hyperactive, contributing to excessive superoxide production and related tissue damage. Although normal neutrophil activation is cooperatively controlled by Ca²⁺-independent and Ca²⁺-linked signaling pathways, exuberant Ca²⁺-linked signaling appears to cause neutrophil hyperactivation in the injury conditions.

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