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Atrial Natriuretic Peptide: Regulator of Chronic Arterial Blood Pressure

Luis Gabriel Melo, Stephen C. Pang and Uwe Ackermann

L. G. Melo and U. Ackermann are in the Department of Physiology of the University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. S. C. Pang is in the Department of Anatomy and Cell Biology, Faculty of Health Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
Recent findings in atrial natriuretic peptide (ANP) transgenic and gene knockout mouse models uncovered a tonic vasodilatory effect of this hormone that contributes to chronic blood pressure homeostasis. With elevated salt intake, ANP-mediated antagonism of the renin-angiotensin system is essential for blood pressure constancy, suggesting that a deficiency in ANP activity may underlie the etiology of sodium-retaining disorders.

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