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News Physiol Sci 15: 161-165, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 4, 161-165, August 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

Toward Understanding the Role of Methylation in Aldosterone-Sensitive Na+ Transport

James D. Stockand, Robert S. Edinger, Douglas C. Eaton and John P. Johnson

J. D. Stockand is in the Department of Physiology, University of Texas Health Science Center San Antonio, San Antonio, Texas 78284-7756. D. C. Eaton is at the Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322; R. S. Edinger and J. P. Johnson are in the Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Proper endocrine regulation of Na+ reabsorption by renal principal cells is the primary means in mammals for maintaining blood pressure. Aldosterone increases Na+ reabsorption by activating luminal Na+ channels; however, the signal transduction pathway of aldosterone is not fully understood. Cellular methylation is necessary for aldosterone signaling to the luminal Na+ channel. We describe the enzymes, regulators, and effectors of aldosterone-mediated methylation relevant to Na+ reabsorption.




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