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News Physiol Sci 15: 165-171, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 4, 165-171, August 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

Ca2+-Activated Cl– Channels: A Newly Emerging Anion Transport Family

Catherine M. Fuller and Dale J. Benos

C. M. Fuller and D. J. Benos are in the Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama 35294.
A new family of Cl– channels widely expressed in epithelia has been identified. These proteins are associated with Ca2+-sensitive conductive Cl– transport when heterologously expressed. This family may underlie the Ca2+-mediated Cl– conductance responsible for rescue of the cystic fibrosis knockout mouse from significant airway disease.




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