Physiology AJP: Heart and Circulatory Physiology
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News Physiol Sci 15: 176-180, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 4, 176-180, August 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

Isoform-Specific Regulation of the Na+-K+ Pump in Heart

R. T. Mathias, I. S. Cohen, J. Gao and Y. Wang

R. T. Mathias, I. S. Cohen, J. Gao, and Y. Wang are in the Department of Physiology and Biophysics and Institute of Molecular Cardiology, State University of New York at Stony Brook, Stony Brook, New York 11794-8661.
Guinea pig ventricular myocytes coexpress two isoforms of the Na+-K+ pump. These two isoforms respond differently to the physical environment and are coupled to autonomic input through different signal transduction cascades. The expression of different isoforms provides each cell type with a mechanism of programming specific responses to environmental changes.




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