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Marshaling the Anti-Inflammatory Influence of the Neuroimmunomodulator -MSH

J. M. Lipton, A. Catania and T. Ichiyama

J. M. Lipton was previously in the Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, Texas 75235-9040 and is now Chief Scientific Officer of ZENGEN, Inc., Woodland, California; A. Catania is in the Neuroimmunomodulation Laboratory, IRCCS Ospedale Maggiore, Milan, Italy 20122; and T. Ichiyama is at the Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, Japan.
Inflammation in peripheral tissues should benefit from a novel focus on descending neuroimmunomodulatory anti-inflammatory influences stemming from CNS receptors for the peptide -MSH. Because activation of glial and peripheral cell receptors modulates inflammatory activity, -MSH peptides may aid treatment of a variety of CNS and peripheral inflammatory disorders. Activation of melanocortin receptors should thus promote control of inflammatory diseases.

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