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Autoregulation of Glucose Production

Luc Tappy, Eric Jéquier and Philippe Schneiter

L. Tappy, E. Jéquier, and P. Schneiter are in the Institute of Physiology, University of Lausanne, 1005 Lausanne, Switzerland.
Glucose itself regulates endogenous glucose production independently of changes in glucoregulatory hormones. In addition, acute stimulation of gluconeogenesis does not increase net glucose production. This indicates autoregulation of glucose production. Glucokinase plays a role in this process by allowing hepatic glucose sensing.

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