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Oxygen Radicals as Messengers in Oxygen-Dependent Gene Expression

Thomas Kietzmann, Joachim Fandrey and Helmut Acker

T. Kietzmann is at the Institut für Biochemie und Molekulare Zellbiologie, Humboldtallee 23, 37073 Göttingen, Germany. J. Fandrey is at the Institut für Physiologie, IG1, Hufelandstrasse 55, 45147 Essen, Germany. H. Acker is at theMax-Planck-Institut für molekulare Physiologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.
Changes in ambient PO₂ need to be sensed to allow long-term adaptation of cellular functions via the regulation of gene activity. The generation of OH• from H₂O₂ in an iron-dependent perinuclear Fenton reaction for triggering gene expression could be the key event in the O₂ signaling pathway.

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