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Neuroprotection and Angiogenesis: Dual Role of Erythropoietin in Brain Ischemia

Hugo H. Marti, Myriam Bernaudin, Edwige Petit and Christian Bauer

H. H. Marti is at the Max-Planck-Institut für Physiologische und Klinische Forschung, W. G. Kerckhoff-Institut, Abteilung Molekulare Zellbiologie, Parkstrasse 1, D-61231 Bad Nauheim, Germany. M. Bernaudin and E. Petit are at l'Université de Caen, UMR 6551-CNRS, IFR47-Neuro-Imagerie Fonctionelle, Bd. Henri Becquerel, BP 5229, F-14074 Caen cedex, France. C. Bauer is at the Physiologisches Institut, Universität Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Erythropoietin, originally defined as an erythroid growth factor, is upregulated in the brain under conditions of hypoxia. So far, two functions have been identified for this locally produced cytokine: a direct protective effect on neuronal cells during cerebral ischemia and an indirect protection of brain tissue that could be provided by promoting brain vessel growth.

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