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News Physiol Sci 15: 250-255, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 5, 250-255, October 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

The Neuroimmune Interface in Prion Diseases

Michael A. Klein and Adriano Aguzzi

M. A. Klein and A. Aguzzi are at the Institute of Neuropathology, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland.
Prion diseases are fatal neurodegenerative disorders of animals and humans. Here we address the role of the immune system in the spread of prions from peripheral sites to the central nervous system and its potential relevance to iatrogenic prion disease.






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