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Tryptophan-Free Diets: A Physiological Tool to Study Brain Serotonin Function

F. Fadda

F. Fadda is in the Department of Biochemistry and Human Physiology, Section of Human Physiology, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy.
Tryptophan-free diets produce a specific reduction of brain serotonin synthesis and release. This method for lowering neural serotonin function has been extensively used in both laboratory animals and humans to study the role of serotonin in a variety of behaviors, such as aggressiveness, sleep, sexual behavior, anxiety, mood, memory, and so forth.

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