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News Physiol Sci 15: 264-268, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 5, 264-268, October 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

Urocortin: A Novel Player in Cardiac Control

David G. Parkes and Clive N. May

D. G. Parkes is at Amylin Pharmaceuticals, 9373 Towne Centre Dr., San Diego, California 92121, and C. N. May is at the Howard Florey Institute of Physiology and Medicine, University of Melbourne, Parkville, Victoria, 3052 Australia.
Urocortin is a potent regulator of cardiac function, with actions that are prolonged in experimental animals. These changes are mediated via binding to corticotropin-releasing factor receptors found in peripheral tissues. The effects of urocortin on behavior, appetite, inflammation, and the cardiovascular system suggest that this peptide may be an endogenous factor mediating actions previously attributed to corticotropin-releasing factor.




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