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No Role for the Ryanodine Receptor in Regulating Cardiac Contraction?

D. A. Eisner and A. W. Trafford

D. A. Eisner and A. W. Trafford are in the Unit of Cardiac Physiology, Faculty of Medicine, The University of Manchester, 1.524 Stopford Building, Manchester M13 9PT, UK.
Cardiac contraction is initiated by Ca²⁺ leaving the sarcoplasmic reticulum through the ryanodine receptor (RyR). Although opening of the RyR can be modified by various ligands, these have no maintained effect on contraction. We conclude that modulation of the RyR controls sarcoplasmic reticulum Ca²⁺ content rather than cytoplasmic Ca²⁺ concentration.

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