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Calmodulin and Excitation-Contraction Coupling

Susan L. Hamilton, Irina Serysheva and Gale M. Strasburg

S. Hamilton is a Professor and I. Serysheva is an Assistant Professor in the Department of Molecular Physiology and Biophysics at Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030. G. M. Strasburg is a Professor in the Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824-1224.
Excitation-contraction coupling in cardiac and skeletal muscle involves the transverse-tubule voltage-dependent Ca²⁺ channel and the sarcoplasmic reticulum Ca²⁺ release channel. Both of these ion channels bind and are modulated by calmodulin in both its Ca²⁺-bound and Ca²⁺-free forms. Calmodulin is, therefore, potentially an important regulator of excitation-contraction coupling. Its precise role, however, has not yet been defined.

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