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News Physiol Sci 15: 284-290, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 6, 284-290, December 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

GABA in the Mammalian Enteric Nervous System

Anthony Krantis

A. Krantis is a Professor in the Department of Cellular and Molecular Medicine, Digestive Diseases Research Group, University of Ottawa, Ottawa, ON, Canada K1H 8M5.
{gamma}-Aminobutyric acid (GABA) is a transmitter of enteric interneurons, targeting excitatory GABAA or inhibitory GABAB receptors that modulate motility and mucosal function. Enteric GABA may also subserve hormonal and paracrine signaling. Disruption in gastrointestinal function following perturbation of enteric GABA receptors presents potential new target sites for drug development.




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