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News Physiol Sci 15: 291-298, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 6, 291-298, December 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

A Novel Pacemaker Mechanism Drives Gastrointestinal Rhythmicity

Kenton M. Sanders, Tamás Ördög, Sang Don Koh and Sean M. Ward

K. M. Sanders, T. Ördög, S. D. Koh, and S. M. Ward are in the Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557.
Electric pacemaker activity drives peristaltic and segmental contractions in the gastrointestinal tract. Interstitial cells of Cajal (ICC) are responsible for spontaneous pacemaker activity. ICC remain rhythmic in culture and generate voltage-independent inward currents via a nonselective cation conductance. Ca2+ release from endoplasmic reticulum and uptake by mitochondria initiates pacemaker currents. This novel mechanism provides the basis for electric rhythmicity in gastrointestinal muscles.




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