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News Physiol Sci 15: 313-318, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 6, 313-318, December 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

Uncoupling Proteins: Do They Have a Role in Body Weight Regulation?

Abdul.G. Dulloo and Sonia Samec

A. G. Dulloo and S. Samec are at the Institute of Physiology, University of Fribourg, CH-1700 Fribourg, Switzerland.
Several members of the mitochondrial carrier protein family are classified as uncoupling proteins. In contrast to the uncoupling protein specific to brown adipose tissue (UCP1), the physiological role of skeletal muscle uncoupling proteins (UCP2 and UCP3) in weight regulation seems more closely associated with the regulation of lipids as fuel substrate than as mediators of adaptive thermogenesis.




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