Physiology AJP: Regulatory, Integrative and Comparative Physiology
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News Physiol Sci 15: 319-325, 2000;
1548-9213/00 $5.00
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News in Physiological Sciences, Vol. 15, No. 6, 319-325, December 2000
© 2000 Int. Union Physiol. Sci./Am. Physiol. Soc.

Toward an Integrative Concept of Control of Total Body Sodium

H. Wolfgang Reinhardt and Erdmann Seeliger

H. W. Reinhardt and E. Seeliger are in the Institut für Physiologie, Universitätsklinikum Charité, Humboldt-Universität zu Berlin, Germany.
Total body sodium (TBSodium) is a major determinant of body water and arterial pressure. Several observations, in particular that of a "sodium memory," indicate that TBSodium is a controlled variable. Various regulatory elements are involved, e.g., the renin-angiotensin-aldosterone system, atrial receptors, and renal arterial pressure. Balance studies in dogs provide new insights into their contributions to TBSodium control.




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