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Propagation of Cell Death During Myocardial Reperfusion

David Garcia-Dorado and Marisol Ruiz-Meana

D. Garcia-Dorado and M. Ruiz-Meana are in the Servicio de Cardiología, Hospital General Universitari Vall d'Hebron, Pg Vall d'Hebron 119-129, 08035 Barcelona, Spain.
During myocardial reperfusion, increased cytosolic Ca²⁺ concentration may cause hypercontracture and cell death. Hypercontracture can propagate to adjacent cells by a gap junction-dependent mechanism. This propagation explains infarct geometry and increases the final extent of necrosis. Its prevention may represent a new therapeutic strategy for treating patients with myocardial infarction.

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