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News Physiol Sci 16: 1-5, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 1, 1-5, February 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

UTP as an Extracellular Signaling Molecule

Eduardo R. Lazarowski and Richard C. Boucher

E. R. Lazarowski and R. C. Boucher are at the School of Medicine, Department of Medicine, The Cystic Fibrosis Treatment and Research Center, University of North Carolina, Chapel Hill, NC 27599-7248.
In addition to their central role in many biochemical processes, uridine nucleotides are important extracellular signaling molecules that regulate a broad spectrum of cell functions via activation of P2Y2, P2Y4, and P2Y6 receptors. Cellular release of UTP provides a mechanism for autocrine control of calcium- or protein kinase C–dependent processes.




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